Dr. Alon Mantel

Alon Mantel

Research Associate

Dr. Mantel is a Research Associate with extensive experience in dermatologic research. He majored in Biotechnology Engineering at Ort Braude College, Israel and received a PhD in Pharmacology from the University of Rochester in New York. His graduate work was conducted under the mentorship of Dr. Alice Pentland from the Department of Dermatology and focused on the investigation of molecular processes that regulate normal skin physiology, and their dysregulation in eczema and skin cancer. At HUSCRI Dr. Mantel is investigating signaling pathways involved in keloids, abnormal scars that expand beyond the borders of the original wound. Specifically of interest is the pathological role of Reactive Oxygen Species in keloid progression and discovery of novel potential molecular targets. Dr. Mantel’s academic achievements include three best presentation awards and several peer-reviewed first author publications.

 Awards/Recognition:

  1. Outstanding Oral & Poster Presentation Award, 1st place out of 25 presenters (2015 Hampton University Skin of Color International Symposium, Williamsburg, VA; awarded $500)
  2. Society of Investigative Dermatology travel award PhD Retreat for Future Investigators (2015; Nominated by my supervisors and selected by the SID committee to receive full sponsorship)
  3. Albert Kligman Travel Fellowship Award (2014; Society of Investigative Dermatology, Albuquerque, NM
  4. Outstanding poster presentation, 1st place out of 16 presenters (2013 Hampton University Skin of Color International Symposium, Baltimore, MD)
  5. Graduate Student Society Merit Award- Recognition for an outstanding presentation of thesis work, 1st place (2011; University of Rochester, Rochester, NY; awarded $500)
  6. Undergraduate Research Scholarship ($9000) Ort Braude College, Israel in collaboration with the University of Rochester, Rochester, NY (2005)

Publications:

  1. Mantel, A.; Mendini, A.B; VanBuskirk, J.; DeBenedetto, A.; Beck, L.A. and Pentland, A.P. “Aldo-keto reductase 1C3 is expressed in differentiated human epidermis, affects keratinocyte differentiation and is upregulated in atopic dermatitis”. J Invest Dermatol 132(4): 1103-1110. (2012)
  2. Mantel, A.; Mendini, A.B.; VanBuskirk, J. and Pentland, A.P. “Aldo-Keto reductase 1C3 (AKR1C3) is highly expressed in cutaneous squamous cell carcinoma (SCC) and affects SCC cell proliferation”. Exp Dermatol 23(8): 573-578. (2014)
  3. Mantel, A.; Harvey, V.M. “P2X7/PANX1 as a new target for melanoma?” Exp Dermatol 24(5): 336-337. (2015)
  4. Mantel A.; Newsome, A. Joseph T., Fraizer R. and Katdare M. “The role of Aldo-keto reductase 1C3 (AKR1C3)-mediated prostaglandin D2 (PGD2) metabolism in keloids” Dermatol 25(1): 38-43. (2016)
  5. Trace, AP; Enos, CW; Mantel,A and Harvey, VM. "Keloids and hypertrophic scars: a spectrum of clinical challenges" American Journal of Clinical Dermatology ISSN: 1175-0561 (Print) 1179-1888 (Online). (2016)